R.P.J. (Bo) de Lange, PhD

Scientific Program Manager

Neurobiologist with knowledge and expertise about the biological mechanisms of disease. Hands-on experience with both practical and theoretical models.

Specialties:

Bridging knowledge engineering and domain expertise.

 

RESUME

Scientific Program Manager at Alan Turing Institute Almere

July 2009 - Present

 

 

Senior Biomedical Scientist at Pharmaps BV

October 2008 - November 2010

Improving Medication Safety by gathering all relevant patient information and applying Clinical Rules using a Reasoning Engine

 

Scientific Researcher at Emotional Brain BV

September 2006 - June 2009

We built (bio)medical knowledge bases and reasoning software to aid (bio)medical professionals.

 

Post-doc Researcher at Rudolf Magnus Institute of Neurosciences, UMC Utrecht

August 2002 - August 2006

We studied changes in the brain due to stress, using a rat model for Posttraumatic Stress Disorder

 

Post-doc Researcher at University of Amsterdam and Erasmus University Rotterdam

October 1999 - July 2002

Neurobiological research into Synaptic Transmission

 

Post-doc Researcher at University of Aberdeen, Scotland, UK

October 1997 - September 1999

Research into CADASIL, the most common form of hereditary stroke disorder

 

Research Assistant at Vrije Universiteit Amsterdam

June 1991 - August 1992

Education and Qualifications

 

Vrije Universiteit Amsterdam

PhD, Biology, 1992 - 1997

 

Vrije Universiteit Amsterdam

MSc, Biology, 1985 - 1991

 

List of Publications

Altelaar, A. F., Klinkert, I., Jalink, K., de Lange, R. P., Adan, R. A., Heeren, R. M., et al. (2006). Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry. Anal. Chem, 78(3), 734– 742.

Altelaar, A. F., Taban, I. M., McDonnell, L. A., Verhaert, P. D., de Lange, R. P., Adan, R. A., et al. (2007). Highresolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections. International Journal of Mass Spectrometry, 260(2-3), 203–211.

Burke, J. F., Kellett, E., De Lange, R. P. J., Santama, N., Saunders, S. E., & Benjamin, P. R. (1992). Neuropeptide FMRFamide gene expression. In Gene expression in neural tissues, Methods in Neurosciences (pp. 64-78). San Diego, CA: Academic press.

Chawda, S. J., De Lange, R. P. J., Hourihan, M. D., Halpin, S. F. S., & St. Clair, D. (2000). Diagnosing CADASIL using MRI: evidence from families with known mutations of Notch 3 gene. Neuroradiology, 42(4), 249–255.

De Jong-Brink, M., Hoek, R. M., Smit, A. B., De Lange, R. P. J., Lageweg, W., Moneypenny, C., et al. (1996). Parasiteinduced physiological changes in its snail host are reflected/caused by affecting neurons and neurosecretory cells in the central nervous system. Molecular Biology Of the Cell, 7(SS), 894.

De Lange, R. P. J., De Boer, P., Ter Maat, A., Tensen, C. P., & Van Minnen, J. (1998). Transmitter identification in neurons involved in male copulation behavior in Lymnaea stagnalis. The Journal of Comparative Neurology, 395(4), 440–449.

De Lange, R. P. J., Geerse, G. J., Dahlhaus, M., van Laar, T. J., Wiegant, V. M., & Stam, R. (2005). Altered brain stem responsivity to duodenal pain after a single stressful experience. Neuroscience letters, 381(1-2), 144–148.

De Lange, R. P. J., Joosse, J., & Van Minnen, J. (1998). Multi-messenger innervation of the male sexual system of Lymnaea stagnalis. The Journal of Comparative Neurology, 390(4), 564–577.

De Lange, R. P. J., Moorer-van Delft, C. M., De Boer, P., van Minnen, J., & de Jong-Brink, M. (2001). Targetdependent differentiation and development of molluscan neurons and neuroendocrine cells: use of parasitisation as a tool. Neuroscience, 103(1), 289–299.

De Lange, R. P. J., Van Golen, F. A., & Van Minnen, J. (1997). Diversity in cell specific co-expression of four neuropeptide genes involved in control of male copulation behaviour in Lymnaea stagnalis. Neuroscience, 78(1), 289–299.

De Lange, R. P. J., & Van Minnen, J. (1998). Localization of the Neuropeptide APGWamide in Gastropod Molluscs byin SituHybridization and Immunocytochemistry. General and comparative endocrinology, 109(2), 166–174.

De Lange, R. P., Burr, K., Clark, J. S., Negrin, C. D., Brosnan, M. J., St Clair, D. M., et al. (2001). Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke. neurogenetics, 3(2), 99–106.

van Golen, F. A., Li, K. W., de Lange, R. P., Jespersen, S., & Geraerts, W. P. (1995). Mutually exclusive neuronal expression of peptides encoded by the FMRFa gene underlies a differential control of copulation in Lymnaea. Journal of Biological Chemistry, 270(47), 28487.

Haritunians, T., Chow, T., De Lange, R. P. J., Nichols, J. T., Ghavimi, D., Dorrani, N., et al. (2005). Functional analysis of a recurrent missense mutation in Notch3 in CADASIL. Journal of Neurology, Neurosurgery, and Psychiatry, 76(9), 1242-1248. doi: 10.1136/jnnp.2004.051854

Hermann, P. M., de Lange, R. P., Pieneman, A. W., ter Maat, A., & Jansen, R. F. (1997). Role of neuropeptides encoded on CDCH-1 gene in the organization of egg-laying behavior in the pond snail, Lymnaea stagnalis. Journal of neurophysiology, 78(6), 2859.

Kalaria, R. N., Low, W. C., Oakley, A. E., Slade, J. Y., Ince, P. G., Morris, C. M., et al. (2002). CADASIL and genetics of cerebral ischaemia. Stroke-vascular Diseases, 75.

Kalaria, R., Cookson, N., Mizuno, T., Oakley, A., Morris, C., Coulthard, A., et al. (2000). Microvascular pathology in familial multiinfarct dementia or CADASIL: implications for cerebral blood flow. In Ischemic blood flow in the brain (pp. 431-442). Hong Kong: Springer-Verlag.

de Lange, R. P., Bolt, J., Reid, E., da Silva, R., Shaw, D. J., & St Clair, D. M. (2000). Screening British CADASIL families for mutations in the NOTCH3 gene. Journal of Medical Genetics, 37(3), 224-225.

De Lange, R. P. J., Minnen, J., & Boer, H. H. (1994). Expression and translation of the egg-laying neuropeptide hormone genes during post-embryonic development of the pond snail Lymnaea stagnalis. Cell and tissue research, 275(2), 369–375.

de Lange, R. P. J., de Roos, A. D. G., & Borst, J. G. G. (2003). Two modes of vesicle recycling in the rat calyx of Held. Journal of Neuroscience, 23(31), 10164.

de Lange, R. P., Wiegant, V. M., & Stam, R. (2008). Altered neuropeptide Y and neurokinin messenger RNA expression and receptor binding in stress-sensitised rats. Brain research, 1212, 35–47.

Leenders, A. G. M., Scholten, G., De Lange, R. P. J., Lopes da Silva, F. H., & Ghijsen, W. (2002). Sequential changes in synaptic vesicle pools and endosome-like organelles during depolarization near the active zone of central nerve terminals. Neuroscience, 109(1), 195–206.

MacLeod, M. J., De Lange, R. P., Breen, G., Meiklejohn, D., Lemmon, H., & Clair, D. S. (2001). Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population. European Journal of Clinical Investigation, 31(7), 570-573.

McDonnell, L. A., Heeren, R. M., de Lange, R. P., & Fletcher, I. W. (2006). Higher sensitivity secondary ion mass spectrometry of biological molecules for high resolution, chemically specific imaging. Journal of the American Society for Mass Spectrometry, 17(9), 1195–1202.

Rodríguez-Contreras, A., de Lange, R. P. J., Lucassen, P. J., & Borst, J. G. G. (2006). Branching of calyceal afferents during postnatal development in the rat auditory brainstem. The Journal of Comparative Neurology, 496(2), 214-228. doi: 10.1002/cne.20918

Stam, R., de Lange, R. P. J., Graveland, H., Verhave, P. S., & Wiegant, V. M. (2007). Involvement of group II metabotropic glutamate receptors in stress-induced behavioural sensitization. Psychopharmacology, 191(2), 365-375. doi: 10.1007/s00213-006-0659-x

Thomas, N. J., Morris, C. M., Scaravilli, F., Johansson, J., Rossor, M., De Lange, R., et al. (2000). Hereditary vascular dementia linked to notch 3 mutations. CADASIL in British families. Ann N Y Acad Sci, 903, 293-8.

Ünlü, M., de Lange, R. P., de Silva, R., Kalaria, R., & St. Clair, D. (2000). Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. Neuroscience letters, 282(3), 149–152.

Van Golen, F. A., Li, K. W., De Lange, R. P. J., Van Kesteren, R. E., Van Der Schors, R. C., & Geraerts, W. P. M. (1995). Co-localized neuropeptides conopressin and Ala-Pro-Gly-Trp-NH2 have antagonistic effects on the vas deferens of Lymnaea. Neuroscience, 69(4), 1275–1287.

Van Kesteren, R., Smit, A., De Lange, R., Kits, K., Van Golen, F., Van Der Schors, R., et al. (1995). Structural and functional evolution of the vasopressin/oxytocin superfamily: vasopressin-related conopressin is the only member present in Lymnaea, and is involved in the control of sexual behavior. J. Neurosci., 15(9), 5989-5998.