J.M. (Anneke) Alkemade, PhD

Senior Researcher Obesity

 

Neurobiologist specialized in neuroendocrinology, research interests: obesity, neuroendocrinology

RESUME

Professional experience

       July 2011-present    

       Senior researcher Obesity, Project leader, Alan Turing Institute Almere

       June 2008- June 2011                        

Post-doc, Dept of Endocrinology and Metabolism, Academic  Medical Center, University of Amsterdam, Amsterdam

December 2007 - May 2008                 

Post-doc, Netherlands Institute for Neuroscience, Amsterdam

September 2005 - November 2007
       
Post-doc, Dept of Cell and Molecular Biology, Karolinska Institutet, Stockholm

27 September 2005         
                    
Defense of doctorate thesis titled:‘Central components of the human Hypothalamus Pituitary Thyroid axis and their role in nonthyroidal illness’.

February 2001- February 2005          

PhD-student, Netherlands Institute for Brain Research, Amsterdam and Department of Endocrinology and Metabolism, Academic Medical Center of Amsterdam, University of Amsterdam, Amsterdam

         30 January 2001                                
         
         Master’s Degree in Pharmaceutical  Sciences, University of Utrecht, Utrecht                           

 
Grants

Grant from the Jan Dekker and Ludgardine Bouwman stichting for ‘Dominant negative mutations in Thyroid hormone receptor alpha 1 (TRa1)’ [PI]

 

ZonMW-Veni-grant from the Netherlands Organization for Health Research and Development for the project ‘Dominant negative mutations in Thyroid hormone receptor alpha 1 (TRa1)’  [PI]

 

Stipend from the Niels Stensen foundation for the project ‘Neurogenesis in mice with a mutant thyroid hormone receptor a1 gene’, for a post doctoral fellowship at the department of Cell and Molecular Biology of the Karolinska Institute, Stockholm, Sweden [PI]

 

ZonMW-Talent stipend from the Netherlands Organization for Health Research and DevelopmentTalent stipend from the Netherlands Organization for Health Research and Development for the project ‘Neurogenesis in mice with a mutant thyroid hormone receptor a1 gene’, for a post doctoral fellowship at the department of Cell and Molecular Biology of the Karolinska Institute, Stockholm, Sweden [PI]

Publications

A Alkemade, EC Friesema, A Kalsbeek, DF Swaab, TJ Visser, E Fliers

Expression of thyroid hormone transporters in the human hypothalamus, J Clin Endocrinol Metab, in press

 

AJ Borgers, N Romeijn, E van Someren, E Fliers, A Alkemade, PH Bisschop

Past compression of the optic chiasm is associated with objective shorter sleep duration in patients with pituitary insufficiency, Clin Endocrinol, in press

 

CX Yi, N Sun, MT Ackermans, A Alkemade, E Foppen, J Shi, MJ Serlie, RM Buijs, E Fliers, A Kalsbeek

Pituitary adenylate cyclase-activating polypeptide (PACAP) signaling to pre-autonomic neurons of the hypothalamic paraventricular nucleus increases endogenous glucose production by stimulating hepatic glycogenolysis; Diabetes, 2010 Jul;59(7):1591-600

 

A Alkemade

Central and peripheral effects of thyroid hormone signaling in the control of energy metabolism. J Neuroendocrinol, 2010 Jan; 22(1):56-63

 

A Alkemade, TJ Visser, E Fliers

Thyroid hormone signalling in the hypothalamus. Curr Opin Endocrinol Diabetes Obes, 2008 Oct;15(5):453-8

 

A Alkemade,M Sjögren, J Mittag, K Nordström, A Katz, B Rozell, H Westerblad, A Arner, B Vennström

Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor a1. EMBO J, 2007, Oct 31;26(21):4535-45

 

E Fliers, A Alkemade, WM Wiersinga, DF Swaab

Hypothalamic thyroid hormone feedback in health and disease. Prog Brain Res, 2006, 153:189-207

 

E Fliers, UA Unmehopa, A Alkemade

Functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and pituitary gland. Mol Cell Endocrinol, 2006, Jun; 251(1-2):1-8

 

A Alkemade, EC Friesema, GG Kuiper, WM Wiersinga, DF Swaab, TJ Visser, E Fliers

Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary.

Eur J Endocrinol. 2006 Mar; 154(3):491-500

 

A Boelen, J Kwakkel, A Alkemade, R Renckens, E Kaptein, G Kuiper, WM Wiersinga, TJ Visser

Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation. Endocrinology 2005 Dec; 146(12):5128-34

 

A Alkemade, EC Friesema, UA Unmehopa, BO Fabriek, GG Kuiper, JL Leonard, WM Wiersinga, DF Swaab, TJ Visser and E Fliers

Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus J Clin Endocrinol Metab, 2005 Jul; 90(7):4322-34

 

A Alkemade, CL Vuijst, UA Unmehopa, O Bakker, B Vennström, WM Wiersinga, DF Swaab and E Fliers

Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary. J Clin Endocrinol Metab, 2005 Feb; 90(2): 904-12

 

A Alkemade, UA. Unmehopa, WM Wiersinga, DF Swaab and E Fliers

Glucocorticoids decrease TRH mRNA expression in the paraventricular nucleus (PVN) of the

human hypothalamus. J Clin Endocrinol Metab, 2005 Jan; 90(1):323-7

 

Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM.

Simultaneous changes in central and peripheral components of the hypothalamus-pituitarythyroid axis in lipopolysaccharide-induced acute illness in mice. J Endocrinol. 2004 Aug;182(2):315-23

 

A Alkemade, UA Unmehopa, JP Brouwer, WJ Hoogendijk, DF Swaab and E Fliers

Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression. Mol Psychiatry. 2003 Oct;8(10):838-9

 

E Fliers, A Alkemade, WM Wiersinga

The hypothalamic-pituitary-thyroid axis in critical illness. Best Pract Res Clin Endocrinol Metab. 2001 Dec;15(4):453-64

 

Working papers

A Alkemade, UA Unmehopa, E.V.S Hessel, DF Swaab, A Kalsbeek, E Fliers

Suppressor of cytokine signaling 3 in the human hypothalamus and its relationship with serum leptin (submitted)

 

A Alkemade, CX Yi, L Pei, M Harakalova, DF Swaab, E Fliers, A Kalsbeek

Decreased aMelanocyte Stimulating Hormone (aMSH) expression in the hypothalamic infundibular nucleus of subjects with type 2 diabetes (submitted)

 

E Bruinstroop, L Pei, MT Ackermans, E Foppen, AJF Borgers, J Kwakkel,A Alkemade, J Shi, E Fliers, A Kalsbeek

Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL triglyceride secretion via the sympathetic nervous system in rats (submitted)

 

ECH Friesema, TJ Visser, AJF Borgers, A Kalsbeek, DF Swaab, E Fliers, A Alkemade

Thyroid hormone transporters and deiodinases in the developing human hypothalamus (submitted)